Neuropsychological function in mild hyperphenylalaninemia

By: Smith, Mary Lou.
Contributor(s): Saltzman, Jennifer | Klim, Paula.
Series: American Journal on Mental Retardation 105 (2) 2000: 69-80.Publisher: 2000Content type: text Media type: unmediated Carrier type: volume Subject(s): PHENYLKETONURIA | COGNITIVE DYSFUNCTION | COGNITIVE DEVELOPMENT | INTELLIGENCE | BEHAVIOURAL ASSESSMENT | EXECUTIVE FUNCTION | PSYCHOLOGICAL ASSESSMENTSummary: This article investigates whether specific congitive deficts related to frontal-lobe dysfunction that have been reported in individuals with phenylketonuria (PKU) are also characteristic of mild hyperhphenylalaninemia (MHP). Tests of executive function and control tasks not assessing executive function were administered to a group of individuals with MHP and a group without MHP, similar in age, gender, and IQ. Tests of academic skills and behaviour-rating questionaires were also administerd to the group with MHP. No group differences were found for any measure, suggesting that the mild elevations of phenylalanine in individuals with MHP are not sufficent to produce behavioural and cognitive impairments characteristic of PKU.[AJ].
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This article investigates whether specific congitive deficts related to frontal-lobe dysfunction that have been reported in individuals with phenylketonuria (PKU) are also characteristic of mild hyperhphenylalaninemia (MHP). Tests of executive function and control tasks not assessing executive function were administered to a group of individuals with MHP and a group without MHP, similar in age, gender, and IQ. Tests of academic skills and behaviour-rating questionaires were also administerd to the group with MHP. No group differences were found for any measure, suggesting that the mild elevations of phenylalanine in individuals with MHP are not sufficent to produce behavioural and cognitive impairments characteristic of PKU.[AJ].

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